Pulmonary Production of Soluble ST2 in Heart Failure

Prognostic Value of Soluble ST2 (sST2) Serum Levels in Infants and Children with Heart Failure Complicating Congenital Heart Disease

Background Heart failure (HF) in infants and children with congenital heart disease (CHD) is a crucial complication with different outcomes. Many biomarkers are used as prognostic indicators. Soluble ST2 (sST2) is one of these markers studied in adults with HF. We aimed to study the prognostic value of sST2 in CHD children with HF. Materials and Methods In current case-control study, thirty-six...

Soluble ST2: A Novel Prognostic Biomarker of Heart Failure.

Previous studies have demonstrated the role of ST2 in predicting hospitalization and mortality in heart failure, independent of natriuretic peptides and other clinical variables. 9-17 In 2011, the U.S. Food and Drug Administration (FDA) delared the Presage ST2 Assay (Critical Diagnostics, San Diego, California, USA), which is typically used in conjunction with clinical evaluation as an aid in a...

Prognostic Value of Soluble ST2 in the Valsartan Heart Failure Trial Anand et al: sST2 in Heart Failure

Prognostic value of soluble ST2 in the Valsartan Heart Failure Trial.

BACKGROUND Soluble ST2 (sST2), a biomarker related to inflammation, is associated with outcomes of patients with heart failure. In-depth analyses of the relationship among sST2, changes in sST2, and patient outcomes are reported. METHODS AND RESULTS sST2 was measured at baseline (n=1650), 4 months (n=1345), and 12 months (n=1094) in Valsartan Heart Failure Trial. Baseline sST2 averaged 28.7±1...

Soluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community‐Dwelling Population

BACKGROUND Soluble ST2 (sST2), a marker of myocyte stretch and fibrosis, has prognostic value in many cardiovascular diseases. We hypothesized that sST2 levels are associated with incident heart failure (HF), including subtypes of preserved (HFpEF) and reduced (HFrEF) ejection fraction, and cardiovascular death. METHODS AND RESULTS Baseline serum sST2 was measured in 3915 older, community-dwe...